Milestone‑first planning
Plan to IND/Ph1/Ph2 gates; map biology and regulatory steps to cash.
Milestone‑first planning. Trial & batch grounded. Assumption governance. Operated monthly.
Plan to IND/Ph1/Ph2 gates; map biology and regulatory steps to cash.
Enrollment/site curves; batch calendars (QC/QA/stability) beat top‑down budgets.
Every driver has owner, source and effective date; the Assumptions Book survives diligence.
Diagnose (Week 0) → Build (Weeks 1–4) → Operate monthly (variance, forecast, decisions).